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Food therapy: green tea, in the prevention and treatment of non-alcoholic fatty liver disease

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• March 18, 2023March 18, 2023
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Green tea can be considered as a functional food at lower risk and treatment for fatty patients with non-alcoholic liver disease, opines a respectable institute.

Nonalcoholic fatty liver disease is a condition caused by excessive accumulation of fat in the liver.

Green tea, a precious beverage, renders numerous health benefits known to almost everyone in Asia and the Western world. However, like yin in nature, herbal medicine or food, long-term injection of large amounts can obstruct the yin-yang balance, inducing “yin excess syndrome” or “yang void syndrome”. , which includes weakened immunity and painful case of GERD, …according to the Yin-Yang theory of traditional Chinese medicine. Adding a slice of ginger will resolve the adversity.

According to the University of Connecticut, Storrs, the efficacy of green tea for the treatment of obese patients with nonalcoholic fatty liver disease is associated with polyphenolic catechins in inducing hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities.

These chemical compounds have also been found to mitigate the onset and progression of NAFLD.

Lead author Dr Masterjohn C said: “(The phytochemical compounds) demonstrate the hepatoprotective properties of green tea and its catechins and the proposed mechanisms by which these specific dietary agents protect against NAFLD.”

Furthermore, in mice fed a high-fat diet for 24 weeks, then injected with EGCG (10, 20, and 40 mg kg(-1) d(-1), ip), for 4 weeks, the researchers found that the mice showed a significant improvement of high-fat diet in induced body weight, grade 2 or 3 hepatic fatty degeneration (steatosis, lobular inflammation, and treated ballooning), severe hyperlipidemia, hyperglycemia, hyperinsulinemia, and insulin resistance.

The phytochemical EGCG, as a function of dose, also enhanced insulin clearance and increased IDE protein expression and enzyme activity at regulated glucose levels in the liver of treated mice.

In fact, EGCG not only promoted weight loss, but also attenuated symptoms in mice with NAFLD.

Promisingly, in the study of green tea polyphenols (GTP) on nonalcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats, investigations also indicated that GTP intervention not only decreased the increase in weight and significantly reduced visceral fat, but also reduced fasting insulin, glucose and serum lipid levels, through better expression of hepatic TG accumulation and cytoplasmic lipid droplets, as well as decreased hepatic lipogenesis and the efflux of triglycerides from the liver.

Taken together, green tea has shown significant improvement in the risk reduction and treatment of non-alcoholic fatty liver disease, across many aspects. But regular intake of large amounts must be taken carefully to avoid toxicity.